SnapShot: F Box Proteins II

mammals f Box Protein substrates Biological functions of substrates kinase(s) Fbxw1/βTRCP1 (Fbxw11/ β-TrCP2) Atf4 txn factor, stress pathways β-Catenin txn activator, Wnt signaling Gsk3 BimEL BH3 homology, induces apoptosis Rsk1, Rsk2 Bora Aurora kinase activator, spindle stability Gsk3, Plk3 Cdc25A phosphatase, CDK activator, cell cycle Chk1 Cdc25B phosphatase, CDK activator, cell cycle Claspin replication/DNA damage response Plk1 Cyclin D1 cyclin, cell cycle Dlg cell contact and polarity Emi1 F box protein, APC/C inhibitor, cell cycle Plk1 FancM helicase, DNA damage response Plk1 Fgd1 GEF, Cdc42 regulation Fgd3 GEF, Cdc42 regulation Ghr receptor, growth hormone signaling H-Ras GTPase, signaling, cell growth Hsf1 txn factor, heat shock response Plk1 Ifnr receptor, cytokine signaling IκBα inhibitor of NF-κB Ikkβ Mcl1 BH3 homology, inhibits apoptosis Gsk3 p100 txn factor, NF-κB signaling Ikkα p105 txn factor, NF-κB signaling Ikkβ p53 txn factor, tumor suppressor Ikk2 p63 txn factor, epithelial differentiation Pc2 transmembrane protein, calcium signaling Pdcd4 EIF4A inhibitor, protein synthesis S6k1 Per1 txn activator, circadian rhythms Ck1ε Per2 txn activator, circadian rhythms Ck1ε Prl-R receptor, growth hormone signaling Pro-caspase 3 caspase, apoptosis Ptt-g1/Securin separase inhibitor, spindle checkpoint Rcan1 calcineurin-dependent signaling Rest txn repressor, cell cycle, differentiation Sipa1l1/Spar GAP, signal transduction Plk2 Smad3 txn factor, BMP/TGF signaling Snail txn repression, EMT Gsk3 Stat-1 txn factor, IFN signaling Wee1 kinase, CDK inhibitor, cell cycle Plk1, Cdk1 Fbxw2 Gcma txn factor, placenta development Fbxw5 Tsc2 GAP, mTOR pathways Fbxw7/ Cdc4 Aurora-A kinase, cell cycle c-Jun txn factor, cell growth/proliferation Gsk3 c-Myb txn factor, cell growth/proliferation Nlk c-Myc txn factor, cell growth/proliferation Gsk3 Cyclin E1/E2 cyclins, cell cycle Cdk2, Gsk3 mTor kinase, mTOR growth pathways Notch1 transmembrane receptor, Notch signaling Cdk8 Pgc-1 txn coactivator, metabolic pathways Gsk3, Mapk Presenilin Notch signaling Src3 histone acetyltransferase, circadian rhythm Srebp txn factor, sterol lipid synthesis Gsk3 Fbxw8 Cyclin D1 cyclin, cell cycle regulation Mapk Irs-1 Cul7 insulin signaling Fbxl1/ SKP2 Brca2 DNA repair Cdk9 kinase, txn elongation Cdt1 pre-RC component, DNA replication Cdk2, Cdk4 Cyclin A cyclin, cell cycle Cyclin D1 cyclin, cell cycle Cyclin E cyclin, cell cycle E2a txn factor, T and B cell development Mapk E2f1 txn factor, cell cycle Foxo1 txn factor, cell growth/proliferation Akt Mef/Elf4 txn factor, cell growth/proliferation Cdk2 Mkp1 phosphatase, ERK signaling Erk Mll histone methyltransferase B-Myb txn factor, cell growth/proliferation c-Myc txn factor, cell growth/proliferation Orc1 origin recognition, DNA replication p21 CDK inhibitor, cell cycle Cdk2 p27 CDK inhibitor, cell cycle Cdk2 p57 CDK inhibitor, cell cycle Cdk2 Rag2 recombinase, VDJ recombination Cdk2 Rassf1 tumor suppressor, microtubule dynamics Cdk4 p130 txn repressor, cell cycle Cdk4, Cdk6 Smad4 txn factor, BMP/TGF signaling Tal1 txn factor, erythroid differentiation Tob1 txn factor, cell growth/proliferation Ubp43 de-Ub enzyme, interferon signaling Fbxl3 Cry1 txn repressor, circadian rhythms Cry2 txn repressor, circadian rhythms Fbxl5 p150Glued SMC ATPase, microtubule dynamics Fbxl6 Tel (Etv6) txn factor, cell growth/proliferation Fbxl12 p57 CDK inhibitor, cell cycle Fbxl20/ Scrapper Rim1 exocytosis, synaptic plasticity